Carolina (23-3, 11-2 Atlantic Coast Conference) used its swarming defense to stifle the Demon Deacons early, keeping the visitors from attempting a field goal for nearly three minutes to open the game. Wake had pulled within six at 22-16 before the Tar Heels went on a 17-4 run that effectively put the game away before halftime.
McDaniel fueled another long run after the break, as the freshman standout scored nine points in a 5-minute stretch that made it 62-31 with 10 minutes to play.
Ruffin-Pratt, who was limited due to a bruised ankle, showed no ill effects in her nine minutes, scoring 13 points on 4-of-6 shooting, including 11 in an 8-minute burst late in the first half.
Chelsea Douglas scored 13 points, including the 1,000th of her career, to lead Wake Forest (11-14, 4-9 ACC).
The Tar Heels outrebounded their in-state counterparts by six and produced 20 points from 23 Deacon turnovers.
UNC has now won three straight since falling at home to Duke and will travel to Florida State on Sunday as part of a stretch of four road games in five. That game in Tallahassee is scheduled for 1 p.m. and will be televised by the ACC Regional Sports Network.