The Tar Heels and Spartans will tip off just after 9 p.m. at the Breslin Center. ESPN will televise the game nationally with Dan Shulman (play-by-play) and Jay Bilas (analyst) on the call.
The game also will be broadcasted nationally on XM/Sirius satellite radio channel 91.
This marks the second consecutive year in which the Tar Heels will play on the road in the ACC/Big Ten Challenge on the home court of the nation's top-ranked team. Last season, Carolina lost at No. 1 Indiana in the event.
Wednesday's game will be UNC's second this season against a ranked opponent. On Nov. 24, the Tar Heels beat No. 3 Louisville in the championship game of the Hall of Fame Tipoff in Uncasville, Conn.
Michigan State is 7-0 in 2013-14 and is coming off a 98-65 win over Mount St. Mary's last Friday. Earlier this season, the Spartans won the Coaches vs. Cancer Classic with wins over Columbia, Portland, Virginia Tech and Oklahoma. MSU also beat Kentucky on Nov. 12 in the Champions Classic in Chicago.
Carolina leads the all-time series with Michigan State, 11-3, and has won six games in a row over the Spartans.
Roy Williams is 6-0 as UNC's head coach against Michigan State and 6-1 overall (going 0-1 at Kansas versus MSU).
In the most recent meeting between the schools, the Tar Heels beat the Spartans 67-55 on Nov. 11, 2011, in the Carrier Classic on the deck of the USS Carl Vinson aircraft carrier in San Diego, Calif. (see more details below).
The Tar Heels are 2-2 against Michigan State in the ACC/Big Ten Challenge with wins in 2009-10 in Chapel Hill and 2008-09 in Detroit and losses on Dec. 1, 1999, in Chapel Hill and on Nov. 29, 2000, in East Lansing.
Carolina is 7-7 in the ACC/Big Ten Challenge with all seven wins coming in the last last 10 years under Williams, who is 7-3 as a head coach in the ACC/Big Ten Challenge.
UNC has 12 wins over No.-1 ranked teams in the Associated Press poll, more than any other school in NCAA history. Carolina is 12-17 against top-ranked teams in the AP poll. Those 12 wins have come against Duke (seven times), Connecticut (once), Illinois (once), NC State (once), Oklahoma (once) and Syracuse (once).