Sunday's 11:30 a.m., final pits the North Carolina freshman against second-seed Robin Anderson of UCLA in a rematch of the ITA/Riviera All-American final that Loeb won 6-4, 6-0, back in October in Pacific Palisades, Calif.
Loeb dominated preseason No.1 Sabrina Santamaria of Southern California to the tune of a 6-2, 6-0, victory on Saturday afternoon at the USTA-Billie Jean King National Tennis Center.
Neither Loeb or Anderson have dropped a single set in four matches thus far at the National Indoors.
Classmate and seventh-seed Hayley Carter also reached the semifinals on Saturday, but was upended by Anderson by the score of 7-5, 6-2.
In doubles, Carter and Loeb fell 8-4 to Auburn's Pleun Burgmans and Emily Flickinger in the consolation bracket semifinals.