Freshman forward Stephanie Mavunga led all scorers with 18 points and added 14 rebounds for Carolina. Sophomore forward Xylina McDaniel added 16 points on 6-of-9 shooting, while junior guard Brittany Rountree had 15 points.
Freshmen guards Diamond DeShields and Allisha Gray each tossed in 14 points and sophomore guard Megan Buckland added 13 points in the runaway victory.
Head coach Sylvia Hatchell may not have been on the bench to open the season as she works through her leukemia treatments up the street at the Lineberger Cancer Center, but her team looked and played her fast-paced brand of basketball.
Carolina forced 32 turnovers and had 16 steals and scored 38 points off those turnovers.
"I think our size and athletic ability gave them a lot of trouble," said Associate head coach Andrew Calder. "I thought we did a good job pushing the basketball, finding open players, and sharing the basketball.
"A lot of plus one passes, which was good teamwork. We had a pretty good balance of getting the ball inside and outside. We need to do a little better on rebounding. Even though you say we won [the rebounding battle] by 20, a lot of that was because of our size and athletic ability."
DeShields canned back-to-back three-pointers in the opening minutes to fuel a 14-6 lead for North Carolina at the 16:45 mark of the first half.
After a called timeout by the Lady Eagles, buckets from McDaniel and Mavunga extended the lead to 18-6 by the first media timeout at 15:20.
A 15-0 run made it 27-6 with under 13 minutes left until halftime. The lead grew to 31-8 after a short jumper in the paint from N'Dea Bryant.
The lead expanded to 37 points, 59-22, after DeShields stopped on a dime and swished a jumper from the top of the key at the 2:09 mark.
Buckland put an exclamation point on the opening half with a three-pointer with 44 seconds left to give Carolina a 64-25 lead, and would go into intermission leading 64-27.
Carolina held a 53-35 rebounding advantage, led by Mavunga's monster effort with 14 caroms. The Tar Heels also had 20 assists on 37 made buckets, led by a superb seven assists with zero turnovers for point guard Latifah Coleman, who also scored six points on the night.
With the game well in hand by halftime, Carolina extended its lead to 40 points on a three-pointer from Gray at the 13:57 mark.
The lead ballooned to 51 points, 97-46, on another three-ball from Buckland with six minutes to go.
Freshman guard Jessica Washington knocked down a 3-pointer in the corner late in the second half to put all 12 Carolina players in the scoring column tonight, and give the Heels a 108-48 advantage with just over two minutes remaining in the game.
Carson-Newman received eight points from Taylor Peterson and seven points each from three other players.
"I think they [Carson-Newman] have a chance in their league to have a pretty good season," added Calder "They're a well coached team. I thought they did some really good stuff out there tonight."
The Tar Heels shot 50.0 percent (37-of-74) from the field and 13-of-31 from three-point land. The Lady Eagles were limited to 26.2 percent shooting.
Carolina will play its final exhibition game Tuesday against Wingate at 6 p.m., at Carmichael Arena.